Sirt1 and Sirt3 Activation Improved Cardiac Function of Diabetic Rats via Modulation of Mitochondrial Function

• Hauptverfasser: Bugga Paramesha (Verfasst von), Mohammed Soheb Anwar (Verfasst von), Himanshu Meghwani (Verfasst von), Subir Kumar Maulik (Verfasst von), Sudheer Kumar Arava (Verfasst von), Sanjay K Banerjee (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-02-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

In the present study, we aimed to evaluate the effect of Sirt1, Sirt3 and combined activation in high fructose diet-induced insulin resistance rat heart and assessed the cardiac function focusing on mitochondrial health and function. We administered the Sirt1 activator; SRT1720 (5 mg/kg, i.p.), Sirt...