Metabolomic study on idiosyncratic liver injury induced by different extracts of Polygonum multiflorum in rats integrated with pattern recognition and enriched pathways analysis

• Main Authors: Chun-yu Li (Author), Can Tu (Author), Dan Gao (Author), Rui-lin Wang (Author), Hai-zhu Zhang (Author), Ming Niu (Author), Rui-yu Li Li (Author), Cong-En Zhang (Author), Rui-sheng Li (Author), Xiao-he Xiao (Author), Mei-hua Yang (Author), Jia-Bo Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, numerous liver injury cases related to a famous Chinese herb- Polygonum Multiflorum (Heshouwu in Chinese) have attracted great attention in many countries. Our previous work showed that Heshouwu-induced hepatotoxicity belonged to idiosyncratic drug-induced liver injury (IDILI). Unfortunat...