Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

• Main Authors: Shizhen Ding (Author), Guotao Lu (Author), Biying Wang (Author), Jie Xiang (Author), Chunxia Hu (Author), Zhijie Lin (Author), Yanbing Ding (Author), Weiming Xiao (Author), Weijuan Gong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Astilbin, as a compound of flavonoids, exerts anti-inflammation, antioxidation, and immune-suppression activities. Decreased activation of NF-κB and p38 MAPK and increased activation of SOCS3 and AMPK have been found in astilbin-treated cells. However, what molecules are docked by astilbin to initia...