Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2

• Hoofdauteurs: Yun-Qing Song (Auteur), Rong-Jing He (Auteur), Dan Pu (Auteur), Xiao-Qing Guan (Auteur), Jin-Hui Shi (Auteur), Yao-Guang Li (Auteur), Jie Hou (Auteur), Shou-Ning Jia (Auteur), Wei-Wei Qin (Auteur), Sheng-Quan Fang (Auteur), Guang-Bo Ge (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan. This study aims to discover efficacious CES2 inhibitors from natural products and to cha...