Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2

• Main Authors: Yun-Qing Song (Author), Rong-Jing He (Author), Dan Pu (Author), Xiao-Qing Guan (Author), Jin-Hui Shi (Author), Yao-Guang Li (Author), Jie Hou (Author), Shou-Ning Jia (Author), Wei-Wei Qin (Author), Sheng-Quan Fang (Author), Guang-Bo Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the small intestine, has been validated as a key therapeutic target to ameliorate the intestinal toxicity caused by irinotecan. This study aims to discover efficacious CES2 inhibitors from natural products and to cha...