Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect

• Main Authors: Sijia Guo (Author), Chenhao Zhang (Author), Haiou Zeng (Author), Yantao Xia (Author), Chenghao Weng (Author), Yichen Deng (Author), Luda Wang (Author), Huan Wang (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is the second deadly cancer in the world and still lacks curative treatment. Aerobic glycolysis, or Warburg effect, is a major resistance mechanism induced by first-line treatment of HCC, sorafenib, and is regulated by the master regulator of metabolism, AMPK. Activati...