Biannual Administrations of Azithromycin and the Gastrointestinal Microbiome of Malawian Children: A Nested Cohort Study Within a Randomized Controlled Trial

• Main Authors: David Chaima (Author), Harry Pickering (Author), John D. Hart (Author), Sarah E. Burr (Author), Joanna Houghton (Author), Kenneth Maleta (Author), Khumbo Kalua (Author), Robin L. Bailey (Author), Martin J. Holland (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Community-level mass treatment with azithromycin has been associated with a mortality benefit in children. However, antibiotic exposures result in disruption of the gut microbiota and repeated exposures may reduce recovery of the gut flora. We conducted a nested cohort study within the framework of...