Sphingosine Kinase 1 Plays an Important Role in Atorvastatin-Mediated Anti-Inflammatory Effect against Acute Lung Injury

• Главные авторы: Lan Wu (Автор), Yan Cheng (Автор), Shunxiang Peng (Автор), Wensheng Zhang (Автор), Chaoxiong Zhang (Автор)
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• Опубликовано: Hindawi Limited, 2021-01-01T00:00:00Z.
• Предметы: article
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Atorvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitor and inhibits cholesterol synthesis. Recently, atorvastatin also showed anti-inflammatory effect in acute lung injury, ameliorating pulmonary gas-blood exchanging function. Sphingosine kinase 1 plays a cen...