Blockade of voltage-gated K+ currents in rat mesenteric arterial smooth muscle cells by MK801

• Main Authors: Jeong Min Kim (Author), Sang Woong Park (Author), Hai Yue Lin (Author), Kyung Chul Shin (Author), Dong Jun Sung (Author), Jae Gon Kim (Author), Hana Cho (Author), Bokyung Kim (Author), Young Min Bae (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MK801 (dizocilpine), a phencyclidine (PCP) derivative, is a potent noncompetitive antagonist of the N-Methyl-D-aspartate receptor (NMDAr). Another PCP derivative, ketamine, was reported to block voltage-gated K+ (Kv) channels, which was independent of NMDAr function. Kv currents are major regulators...