Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B

• Main Authors: Rita Meleddu (Author), Simona Distinto (Author), Roberto Cirilli (Author), Stefano Alcaro (Author), Matilde Yanez (Author), Maria Luisa Sanna (Author), Angela Corona (Author), Claudia Melis (Author), Giulia Bianco (Author), Peter Matyus (Author), Filippo Cottiglia (Author), Elias Maccioni (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range. The best performing compound was preliminarily eva...