Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis

• Main Authors: Shujin Wang (Author), Francesco Schianchi (Author), Dietbert Neumann (Author), Li-Yen Wong (Author), Aomin Sun (Author), Frans A. van Nieuwenhoven (Author), Maurice P. Zeegers (Author), Agnieszka Strzelecka (Author), Umare Col (Author), Jan F.C. Glatz (Author), Miranda Nabben (Author), Joost J.F.P. Luiken (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid oversupply...