Influence of Acoustic Parameters and Sonication Schemes on Transcranial Blood-Brain Barrier Disruption Induced by Pulsed Weakly Focused Ultrasound

• Main Authors: Yu-Hone Hsu (Author), Wei-Chung Lee (Author), Shing-Shung Chu (Author), Meng-En Chao (Author), Kuo-Sheng Wu (Author), Ren-Shyan Liu (Author), Tai-Tong Wong (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulsed ultrasound combined with microbubbles use can disrupt the blood-brain barrier (BBB) temporarily; this technique opens a temporal window to deliver large therapeutic molecules into brain tissue. There are published studies to discuss the efficacy and safety of the different ultrasound paramete...