Parietal epithelial cells maintain the epithelial cell continuum forming Bowman's space in focal segmental glomerulosclerosis

• Main Authors: Laura Miesen (Author), Péter Bándi (Author), Brigith Willemsen (Author), Fieke Mooren (Author), Thiago Strieder (Author), Eva Boldrini (Author), Vedran Drenic (Author), Jennifer Eymael (Author), Roy Wetzels (Author), Johannes Lotz (Author), Nick Weiss (Author), Eric Steenbergen (Author), Toin H. van Kuppevelt (Author), Merijn van Erp (Author), Jeroen van der Laak (Author), Nicole Endlich (Author), Marcus J. Moeller (Author), Jack F. M. Wetzels (Author), Jitske Jansen (Author), Bart Smeets (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the glomerulus, Bowman's space is formed by a continuum of glomerular epithelial cells. In focal segmental glomerulosclerosis (FSGS), glomeruli show segmental scarring, a result of activated parietal epithelial cells (PECs) invading the glomerular tuft. The segmental scars interrupt the epit...