Dimethyl Itaconate Attenuates CFA-Induced Inflammatory Pain via the NLRP3/ IL-1β Signaling Pathway

• Main Authors: Jiaqi Lin (Author), Jinxuan Ren (Author), Bin Zhu (Author), Yi Dai (Author), Dave Schwinn Gao (Author), Suyun Xia (Author), Zhenzhen Cheng (Author), Yangyuxin Huang (Author), Lina Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itaconate plays a prominent role in anti-inflammatory effects and has gradually been ushered as a promising drug candidate for treating inflammatory diseases. However, its significance and underlying mechanism for inflammatory pain remain unexplored. In the current study, we investigated the effects...