AAV-regulated Serpine2 overexpression promotes hair cell regeneration

• Main Authors: Qiuhan Sun (Author), Fangzhi Tan (Author), Xinlin Wang (Author), Xingliang Gu (Author), Xin Chen (Author), Yicheng Lu (Author), Nianci Li (Author), Xiaoyun Qian (Author), Yinyi Zhou (Author), Ziyu Zhang (Author), Man Wang (Author), Liyan Zhang (Author), Busheng Tong (Author), Jieyu Qi (Author), Renjie Chai (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inner ear hair cell (HC) damage is irreversible in mammals, but it has been shown that supporting cells (SCs) have the potential to differentiate into HCs. Serpine2, a serine protease inhibitor, encodes protease nexin 1, and this has been suggested to be a factor that promotes HC regeneration. In th...