Identification of allele-specific KIV-2 repeats and impact on Lp(a) measurements for cardiovascular disease risk

• Main Authors: Sairam Behera (Author), Jonathan R. Belyeu (Author), Xiao Chen (Author), Luis F. Paulin (Author), Ngoc Quynh H. Nguyen (Author), Emma Newman (Author), Medhat Mahmoud (Author), Vipin K. Menon (Author), Qibin Qi (Author), Parag Joshi (Author), Santica Marcovina (Author), Massimiliano Rossi (Author), Eric Roller (Author), James Han (Author), Vitor Onuchic (Author), Christy L. Avery (Author), Christie M. Ballantyne (Author), Carlos J. Rodriguez (Author), Robert C. Kaplan (Author), Donna M. Muzny (Author), Ginger A. Metcalf (Author), Richard A. Gibbs (Author), Bing Yu (Author), Eric Boerwinkle (Author), Michael A. Eberle (Author), Fritz J. Sedlazeck (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The abundance of Lp(a) protein holds significant implications for the risk of cardiovascular disease (CVD), which is directly impacted by the copy number (CN) of KIV-2, a 5.5 kbp sub-region. KIV-2 is highly polymorphic in the population and accurate analysis is challenging. In this study, w...