Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

• Main Authors: Justin P. Hardee (Author), Karen J.B. Martins (Author), Paula M. Miotto (Author), James G. Ryall (Author), Stefan M. Gehrig (Author), Boris Reljic (Author), Timur Naim (Author), Jin D. Chung (Author), Jen Trieu (Author), Kristy Swiderski (Author), Ashleigh M. Philp (Author), Andrew Philp (Author), Matthew J. Watt (Author), David A. Stroud (Author), Rene Koopman (Author), Gregory R. Steinberg (Author), Gordon S. Lynch (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscular dystrophy (DMD). Promoting an oxidative phenotype could protect muscles from damage and ameliorate the dystrophic pathology with therapeutic relevance, but developing...