Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus

• Main Authors: Mattias Backman (Author), Florian Flenkenthaler (Author), Andreas Blutke (Author), Maik Dahlhoff (Author), Erik Ländström (Author), Simone Renner (Author), Julia Philippou-Massier (Author), Stefan Krebs (Author), Birgit Rathkolb (Author), Cornelia Prehn (Author), Michal Grzybek (Author), Ünal Coskun (Author), Michael Rothe (Author), Jerzy Adamski (Author), Martin Hrabĕ de Angelis (Author), Rüdiger Wanke (Author), Thomas Fröhlich (Author), Georg J. Arnold (Author), Helmut Blum (Author), Eckhard Wolf (Author)
• Format: Book
• Published: Elsevier, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The liver regulates the availability of insulin to other tissues and is the first line insulin response organ physiologically exposed to higher insulin concentrations than the periphery. Basal insulin during fasting inhibits hepatic gluconeogenesis and glycogenolysis, whereas postprandial...