ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

• Main Authors: Erica Staurenghi (Author), Valerio Leoni (Author), Marco Lo Iacono (Author), Barbara Sottero (Author), Gabriella Testa (Author), Serena Giannelli (Author), Gabriella Leonarduzzi (Author), Paola Gamba (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The strongest genetic risk factor for sporadic Alzheimer's disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers of cholesterol and ApoE in the brain, we investig...