Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.

• Main Authors: Marvin Madrigal (Author), Davinia Pla (Author), Libia Sanz (Author), Elexandra Barboza (Author), Cynthia Arroyo-Portilla (Author), Carlos Corrêa-Netto (Author), José María Gutiérrez (Author), Alberto Alape-Girón (Author), Marietta Flores-Díaz (Author), Juan J Calvete (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bothrops, Crotalus and Lachesis represent the most medically relevant genera of pitvipers in Central and South America. Similarity in venom phenotype and physiopathological profile of envenomings caused by the four nominal Lachesis species led us to hypothesize that an antivenom prepared against ven...