Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

• Main Authors: Daichi Yamasoba (Author), Maho Tsubota (Author), Risa Domoto (Author), Fumiko Sekiguchi (Author), Hiroyuki Nishikawa (Author), Keyue Liu (Author), Masahiro Nishibori (Author), Hiroyasu Ishikura (Author), Tetsushi Yamamoto (Author), Atsushi Taga (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nuclear HMGB1 that contains 3 cysteine residues is acetylated and secreted to the extracellular space, promoting inflammation via multiple molecules such as RAGE and TLR4. We thus evaluated and characterized the redox state-dependent effects of peripheral HMGB1 on nociception. Intraplantar (i.pl.) a...