Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products

N6-Methyladenosine (m6A) is the most prevalent mRNA modification in mammalian cells that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and methyltransferase-like 14 (METTL3-METTL14). Many lines of evidence suggest that METTL3 plays important roles in several diseas...

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Main Authors: Yue Du (Author), Yongliang Yuan (Author), Le Xu (Author), Fang Zhao (Author), Wenbin Wang (Author), Yiping Xu (Author), Xin Tian (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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