Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products

• Main Authors: Yue Du (Author), Yongliang Yuan (Author), Le Xu (Author), Fang Zhao (Author), Wenbin Wang (Author), Yiping Xu (Author), Xin Tian (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

N6-Methyladenosine (m6A) is the most prevalent mRNA modification in mammalian cells that is mainly catalyzed by the methyltransferase complex of methyltransferase-like 3 and methyltransferase-like 14 (METTL3-METTL14). Many lines of evidence suggest that METTL3 plays important roles in several diseas...