Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors

• Main Authors: Yue Zeng (Author), Yueming Zheng (Author), Tongtong Zhang (Author), Fei Ye (Author), Li Zhan (Author), Zengwei Kou (Author), Shujia Zhu (Author), Zhaobing Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-methyl-D-aspartate receptors (NMDARs) are Ca2+-permeable ionotropic glutamate receptors (iGluRs) in the central nervous system and play important roles in neuronal development and synaptic plasticity. Conventional NMDARs, which typically comprise GluN1 and GluN2 subunits, have different biophysica...