Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design.

• Main Authors: Edwin Chen (Author), Nichole D Salinas (Author), Francis B Ntumngia (Author), John H Adams (Author), Niraj H Tolia (Author)
• 格式: 图书
• 出版: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine development. DEKnull is a synthetic DBP based antigen that...