Structural analysis of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for Plasmodium vivax malaria vaccine design.

• Główni autorzy: Edwin Chen (Autor), Nichole D Salinas (Autor), Francis B Ntumngia (Autor), John H Adams (Autor), Niraj H Tolia (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes. The polymorphic nature of DBP induces strain-specific immune responses that pose unique challenges for vaccine development. DEKnull is a synthetic DBP based antigen that...