Influence of quercetin and chrysin on the intestinal permeability of paclitaxel, a substrate of P-glycoprotein and CYP3A4 using in vitro rat gut sacs

P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) play a significant role in the disposition and elimination of drugs. The objective of this study was to investigate the mechanism underlying the interaction between paclitaxel (substrate of P-gp and CYP3A4) and quercetin and chrysin (known modul...

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Main Authors: Ravindra Babu Pingili (Author), Manasa Aparna Kambhampati (Author), Sowjanya Vaka (Author), Naveen Babu Kilaru (Author)
Format: Book
Published: Shiraz University of Medical Sciences, 2019-09-01T00:00:00Z.
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