Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis

• Main Authors: Zhan-Ming Li (Author), Chao-Yue Kong (Author), Yu-Qin Mao (Author), Hui-Ling Chen (Author), Shi-Long Zhang (Author), Jia-Ting Huang (Author), Jin-Qing Yao (Author), Pei-Ran Cai (Author), Nuo Xie (Author), Bing Han (Author), Li-Shun Wang (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonalcoholic steatohepatitis (NASH) is the major cause of liver dysfunction. Animal and population studies have shown that mitochondrial aldehyde dehydrogenase (ALDH2) is implicated in fatty liver disease. However, the role of ALDH2 in NASH and the underlying mechanisms remains unclear. To address t...