DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways

• Κύριοι συγγραφείς: Zaid H. Maayah (Συγγραφέας), Ti Zhang (Συγγραφέας), Marcus Laird Forrest (Συγγραφέας), Samaa Alrushaid (Συγγραφέας), Michael R. Doschak (Συγγραφέας), Neal M. Davies (Συγγραφέας), Ayman O. S. El-Kadi (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2018-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Doxorubicin (DOX) is a very potent and effective anticancer agent. However, the effectiveness of DOX in osteosarcoma is usually limited by the acquired drug resistance. Recently, Vitamin D (Vit-D) was shown to suppress the growth of many human cancer cells. Taken together, we synthesized DOX-Vit D b...