Circulating extracellular vesicles from patients with traumatic brain injury induce cerebrovascular endothelial dysfunction

• Main Authors: Lei Li (Author), Fanjian Li (Author), Xuesong Bai (Author), Haoran Jia (Author), Cong Wang (Author), Peng Li (Author), Qiaoling Zhang (Author), Siyu Guan (Author), Ruilong Peng (Author), Shu Zhang (Author), Jing-fei Dong (Author), Jianning Zhang (Author), Xin Xu (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial dysfunction is a key proponent of pathophysiological process of traumatic brain injury (TBI). We previously demonstrated that extracellular vesicles (EVs) released from injured brains led to endothelial barrier disruption and vascular leakage. However, the molecular mechanisms of this EV...