Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

• Main Authors: Lixuan Wang (Author), Rongchun Yang (Author), Yue Kong (Author), Jing Zhou (Author), Yingyao Chen (Author), Rui Li (Author), Chuwen Chen (Author), Xinran Tang (Author), Xiaobing Chen (Author), Juan Xia (Author), Xijuan Chen (Author), Bin Cheng (Author), Xianyue Ren (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment (TME), which significantly compromises the clinical outcomes and responses to therapy in head and neck squamous cell carcinoma (HNSCC) patients. This high...