The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

• Main Authors: Livia Misuri (Author), Mario Cappiello (Author), Francesco Balestri (Author), Roberta Moschini (Author), Vito Barracco (Author), Umberto Mura (Author), Antonella Del-Corso (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. AR is subjected to intense inhibition studies and dimethyl sulfoxide (DMSO) is often prese...