Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis

• Main Authors: Aiyu Peng (Author), Chunmei Gong (Author), Yuanfei Xu (Author), Xiongshun Liang (Author), Xiaoping Chen (Author), Wenxu Hong (Author), Junxia Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundVariants in organic cation transporter (OCT) genes play a crucial role in metformin pharmacokinetics and are critical for diabetes treatment. However, studies investigating the effect of OCT genetic polymorphisms on metformin response have reported inconsistent results. This review and met...