Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports

• Autori principali: Yue Zeng (Autore), Yuanqing Feng (Autore), Guihua Fu (Autore), Junlan Jiang (Autore), Xiaohan Liu (Autore), Yue Pan (Autore), Chunhong Hu (Autore), Xianling Liu (Autore), Fang Wu (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is inevitable and heterogeneous. The strategies to overcome acquired resistance are significant. For patients with secondary T790M-positive after early generation EGFR-TKIs, osimertinib is the standard...