Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG₁₀₀₀]-<i>b</i>-[PLLA] Multi-Block Copolymers in Healthy Horse Joints

• Main Authors: Stefan M. Cokelaere (Author), Wilhelmina M.G.A.C. Groen (Author), Saskia G.M. Plomp (Author), Janny C. de Grauw (Author), Paul M. van Midwoud (Author), Harrie H. Weinans (Author), Chris H.A. van de Lest (Author), Marianna A. Tryfonidou (Author), P. René van Weeren (Author), Nicoline M. Korthagen (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this study, the intra-articular tolerability and suitability for local and sustaine...