Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG₁₀₀₀]-<i>b</i>-[PLLA] Multi-Block Copolymers in Healthy Horse Joints

• मुख्य लेखकों: Stefan M. Cokelaere (लेखक), Wilhelmina M.G.A.C. Groen (लेखक), Saskia G.M. Plomp (लेखक), Janny C. de Grauw (लेखक), Paul M. van Midwoud (लेखक), Harrie H. Weinans (लेखक), Chris H.A. van de Lest (लेखक), Marianna A. Tryfonidou (लेखक), P. René van Weeren (लेखक), Nicoline M. Korthagen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this study, the intra-articular tolerability and suitability for local and sustaine...