Establishment of Stable Cell Lines With High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction With α-Alkyl Moieties

• Main Authors: Narakorn Khunweeraphong (Author), Shushi Nagamori (Author), Pattama Wiriyasermkul (Author), Yumiko Nishinaka (Author), Printip Wongthai (Author), Ryuichi Ohgaki (Author), Hidekazu Tanaka (Author), Hideyuki Tominaga (Author), Hiroyuki Sakurai (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

System L is a major transport system for cellular uptake of neutral amino acids. Among system L transporters, L-type amino acid transporter 1 (LAT1) is responsible for the nutrient uptake in cancer cells, whereas L-type amino acid transporter 2 (LAT2) is a transporter for non-cancer cells. In this s...