INTRODUCTION OF AN N-GLYCOSYLATION SITE INTO UDP-GLUCURONOSYLTRANSFERASE 2B3 ALTERS ITS SENSITIVITY TO CYTOCHROME P450 3A1-DEPENDENT MODULATION

• Main Authors: Tatsuro Nakamura (Author), Naho Yamaguchi (Author), Yuu Miyauchi (Author), Tomoki Takeda (Author), Yasushi Yamazoe (Author), Kiyoshi Nagata (Author), Peter I Mackenzie (Author), Hideyuki Yamada (Author), Yuji Ishii (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our previous studies have demonstrated functional protein-protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood. To address this issue, we examined whether CYP3A...