INTRODUCTION OF AN N-GLYCOSYLATION SITE INTO UDP-GLUCURONOSYLTRANSFERASE 2B3 ALTERS ITS SENSITIVITY TO CYTOCHROME P450 3A1-DEPENDENT MODULATION
Our previous studies have demonstrated functional protein-protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood. To address this issue, we examined whether CYP3A...
Saved in:
Main Authors: | Tatsuro Nakamura (Author), Naho Yamaguchi (Author), Yuu Miyauchi (Author), Tomoki Takeda (Author), Yasushi Yamazoe (Author), Kiyoshi Nagata (Author), Peter I Mackenzie (Author), Hideyuki Yamada (Author), Yuji Ishii (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2016-11-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
by: Yun Sheng, et al.
Published: (2021) -
Pharmacokinetic drug-drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP‐glucuronosyltransferases
by: Sejung Hwang, et al.
Published: (2024) -
Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation
by: Riya Shrestha, et al.
Published: (2018) -
Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite
by: Shuaibing Liu, et al.
Published: (2021) -
Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4
by: Yuu Miyauchi, et al.
Published: (2022)