Interplay between microbial‐derived GABA and host GABA receptor signaling collectively influence the tumorigenic function of GABA in colon cancer

• Main Authors: Jonathan M. Keane (Author), Philana Fernandes (Author), Florian Kratz (Author), Grace O'Callaghan (Author), Cormac G. M. Gahan (Author), Susan A. Joyce (Author), Catherine Stanton (Author), Niall P. Hyland (Author), Aileen Houston (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABAA and GABAB receptors have been implicated in contributing to the effects of G...