Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats

• Main Authors: Fabricio M. Locatelli (Author), Takashi Kawano (Author), Hideki Iwata (Author), Bun Aoyama (Author), Satoru Eguchi (Author), Atsushi Nishigaki (Author), Daiki Yamanaka (Author), Hiroki Tateiwa (Author), Marie Shigematsu-Locatelli (Author), Masataka Yokoyama (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The maladaptive response of aged microglia to surgery and consequent neuroinflammation plays a key pathogenic role in postoperative cognitive dysfunction (POCD). Here, we assessed the preventive effect of resveratrol (RESV) for POCD in aged rats. The emulsified form of RESV (e-RESV) was selected to...