Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains

Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains

Anticalin® proteins have been proven as versatile clinical stage biotherapeutics. Due to their small size (∼20 kDa), they harbor a short intrinsic plasma half-life which can be extended, e.g., by fusion with IgG or Fc. However, for antagonism of co-immunostimulatory Tumor Necrosis Factor Receptor Su...

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Main Authors: Martin Siegemund (Author), Prajakta Oak (Author), Eva-Maria Hansbauer (Author), Andrea Allersdorfer (Author), Karoline Utschick (Author), Alexandra Winter (Author), Christina Grasmüller (Author), Gunther Galler (Author), Jan-Peter Mayer (Author), Benjamin Weiche (Author), Josef Prassler (Author), Roland E. Kontermann (Author), Christine Rothe (Author)
Format: Book
Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
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