Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model

• Main Authors: Shan Cheng (Author), Pan Jin (Author), Heying Li (Author), Duanqing Pei (Author), Xiaodong Shu (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Tyrosine kinase inhibitors (TKIs) to BCR-ABL1 have been successfully used to treat chronic myeloid leukemia (CML), however, multiple TKI-associated adverse events have been reported and become an emerging problem in patients. The mechanisms of TKI-induced toxicity are not fully understood and it rem...