BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plants

• Main Authors: Cole Anthony LJ (Author), Majeed Abu (Author), Lim Siong (Author), James Richard (Author), Harun Azzeme (Author), Ramasamy Kalavathy (Author)
• Format: Book
• Published: BMC, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>BACE1 was found to be the major β-secretase in neurons and its appearance and activity were found to be elevated in the brains of AD patients. Fungal endophytic extracts for BACE1 inhibitory activity and cytotoxicity against PC-12 (a...