Anti-hepatitis B Virus Activity of α-DDB-FNCG, a Novel Nucleoside-Biphenyldicarboxylate Compound In Vitro and In Vivo

• Main Authors: Qinghua Yang (Author), Xuejie Zhao (Author), Wenquan Yu (Author), Wu He (Author), Xianzhen Fang (Author), Limin Zang (Author), Na Wan (Author), Qingduan Wang (Author), Liyun Zheng (Author), Junbiao Chang (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: A novel codrug, α-DDB-FNCG, was synthesized through coupling of α-biphenyl dimethyl dicarboxylate (α-DDB) and the nucleoside analogue FNCG, via an ester bond. The anti-HBV activity and hepatoprotective effects of this compound were investigated both in vitro and in vivo. In HBV-transfecte...