Anti-hepatitis B Virus Activity of α-DDB-FNCG, a Novel Nucleoside-Biphenyldicarboxylate Compound In Vitro and In Vivo
Abstract.: A novel codrug, α-DDB-FNCG, was synthesized through coupling of α-biphenyl dimethyl dicarboxylate (α-DDB) and the nucleoside analogue FNCG, via an ester bond. The anti-HBV activity and hepatoprotective effects of this compound were investigated both in vitro and in vivo. In HBV-transfecte...
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Main Authors: | Qinghua Yang (Author), Xuejie Zhao (Author), Wenquan Yu (Author), Wu He (Author), Xianzhen Fang (Author), Limin Zang (Author), Na Wan (Author), Qingduan Wang (Author), Liyun Zheng (Author), Junbiao Chang (Author) |
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Format: | Book |
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Elsevier,
2014-04-01T00:00:00Z.
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