Distribution of nanoparticles throughout the cerebral cortex of rodents and non-human primates: Implications for gene and drug therapy

• Main Authors: Ernesto A Salegio (Author), Hillary eStreeter (Author), Nikhil eDube (Author), Piotr eHadaczek (Author), Lluis eSamaranch (Author), Adrian eKells (Author), Waldy eSan Sebastián (Author), Yuying eZhai (Author), John eBringas (Author), Ting eXu (Author), John eForsayeth (Author), Krystof S Bankiewicz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

When nanoparticles/proteins are infused into the brain, they are often transported to distal sites in a manner that is dependent both on the characteristics of the infusate and the region targeted. We have previously shown that AAV is disseminated within the brain by perivascular flow and also by ax...