A validated LCâMS/MS method for the determination of tolterodine and its metabolite in rat plasma and application to pharmacokinetic study

• Main Authors: Rihana Parveen Shaik (Author), Srinivasa Babu Puttagunta (Author), Chandrasekhar Bannoth Kothapalli (Author), Bahlul Zayed Sh. Awen (Author), B.R. Challa (Author)
• Format: Book
• Published: Elsevier, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liquid chromatographyâtandem mass spectrometry (LCâMS/MS) method was used for simultaneous quantification of tolterodine and its metabolite 5-hydroxy methyl tolterodine in rat plasma. Tolterodine-d6 and 5-hydroxy methyl tolterodine-d14 were used as internal standards (IS). Chromatographic separation...