Design, Synthesis, and Repurposing of Rosmarinic Acid-β-Amino-α-Ketoamide Hybrids as Antileishmanial Agents

• Main Authors: Ahmed H.E. Hassan (Author), Waleed A. Bayoumi (Author), Selwan M. El-Sayed (Author), Trong-Nhat Phan (Author), Taegeun Oh (Author), Gyeongpyo Ham (Author), Kazem Mahmoud (Author), Joo Hwan No (Author), Yong Sup Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds. Two hybrids, <b>2g</b> and <b>2h,</b> showed promising activity (IC₅₀ values of 9.5 and 8...