Design, Synthesis, and Repurposing of Rosmarinic Acid-β-Amino-α-Ketoamide Hybrids as Antileishmanial Agents

• Main Authors: Ahmed H.E. Hassan (Author), Waleed A. Bayoumi (Author), Selwan M. El-Sayed (Author), Trong-Nhat Phan (Author), Taegeun Oh (Author), Gyeongpyo Ham (Author), Kazem Mahmoud (Author), Joo Hwan No (Author), Yong Sup Lee (Author)
• 格式: 图书
• 出版: MDPI AG, 2023-11-01T00:00:00Z.
• 主题: article
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A series of rosmarinic acid-β-amino-α-ketoamide hybrids were synthesized and rationally repurposed towards the identification of new antileishmanial hit compounds. Two hybrids, <b>2g</b> and <b>2h,</b> showed promising activity (IC₅₀ values of 9.5 and 8...