SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

The study is based on using SeDeM expert system in developing controlled-release tramadol HCl osmotic tablets and its in-silico physiologically based pharmacokinetic (PBPK) modeling for in-vivo pharmacokinetic evaluation. A Quality by Design (QbD) based approach in developing SeDEM-driven full facto...

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Main Authors: Muhammad Talha Saleem (Author), Muhammad Harris Shoaib (Author), Rabia Ismail Yousuf (Author), Farrukh Rafiq Ahmed (Author), Kamran Ahmed (Author), Fahad Siddiqui (Author), Zafar Alam Mahmood (Author), Muhammad Sikandar (Author), Muhammad Suleman Imtiaz (Author)
Format: Book
Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
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