SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™
The study is based on using SeDeM expert system in developing controlled-release tramadol HCl osmotic tablets and its in-silico physiologically based pharmacokinetic (PBPK) modeling for in-vivo pharmacokinetic evaluation. A Quality by Design (QbD) based approach in developing SeDEM-driven full facto...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-10-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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