Development of a Novel Human Single Chain Antibody Against EGFRVIII Antigen by Phage Display Technology

• Main Authors: Leila Rahbarnia (Author), Safar Farajnia (Author), Hossein Babaei (Author), Jafar Majidi (Author), Bahman Akbari (Author), Shiva Ahdi khosroshahi (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: EGFRvIII as the most common mutant variant of the epidermal growth factor receptor is resulting from deletion of exons 2-7 in the coding sequence and junction of exons 1 and 8 through a novel glycine residue. EGFRvIII is highly expressed in glioblastoma, carcinoma of the breast, ovary, and...