Development of a Novel Human Single Chain Antibody Against EGFRVIII Antigen by Phage Display Technology

• Hlavní autoři: Leila Rahbarnia (Autor), Safar Farajnia (Autor), Hossein Babaei (Autor), Jafar Majidi (Autor), Bahman Akbari (Autor), Shiva Ahdi khosroshahi (Autor)
• Médium: Kniha
• Vydáno: Tabriz University of Medical Sciences, 2016-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Purpose: EGFRvIII as the most common mutant variant of the epidermal growth factor receptor is resulting from deletion of exons 2-7 in the coding sequence and junction of exons 1 and 8 through a novel glycine residue. EGFRvIII is highly expressed in glioblastoma, carcinoma of the breast, ovary, and...